In VitroEfficacy of Brincidofovir against Variola Virus
نویسندگان
چکیده
منابع مشابه
Smallpox eradication. Destruction of variola virus stocks.
1. The global eradication of smallpox was confirmed in 1980 (resolution WHA33.3). From 1981 to 1986, WHO undertook a programme to implement the post-eradication policies contained in the 1979 report of the Global Commission for the Certification of Smallpox Eradication and endorsed by the Health Assembly in resolution WHA33.4. Progress was reviewed year by year from 1981 to 1984 by the WHO Comm...
متن کاملExperimental Treatment of Ebola Virus Disease with Brincidofovir
BACKGROUND The nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health Organisation list of agents that should be prioritised for clinical evaluation in patients with Ebola virus disease (EVD) during the West Afr...
متن کاملImmunofluorescence staining for detection of variola virus.
In September 1975 Bangladesh was the only country in the world with endemic variola major, and the eradication of the disease was imminent. A rapid and accurate laboratory diagnostic method was required to supplement immunodiffusion in agar gel and culture on chorioallantoic membrane of embryonated egg available at the Institute of Public Health in Dacca, Bangladesh. To determine its effectiven...
متن کاملThe Origin of the Variola Virus
The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus. In the last century, smallpox was declared eradicated from the human community; however, the mechanisms responsible for the emergence of new dangerous ...
متن کاملSusceptibility of suckling mice to variola virus.
Marshall, Ronald G. (Army Chemical Corps, Fredrick, Md.), and Peter J. Gerone. Susceptibility of suckling mice to variola virus. J. Bacteriol. 82:15-19. 1961.-The susceptibility of suckling mice inoculated intraperitoneally or intracerebrally with variola virus was investigated. Data are presented that define the death patterns, the relationship of incubation period to dose of virus inoculated,...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02814-14